The Reaction Sequence in Ergothioneine Biosynthesis: Hercynine as an Intermediate
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چکیده
منابع مشابه
The reaction sequence in ergothioneine biosynthesis: hercynine as an intermediate.
Ergothioneine can be synthesized by the mold, Neurospora crassa, from the amino acids, histidine, methionine, and cysteine (1). The intact histidine molecule is used in the synthesis, and the three methyl groups of the betaine moiety can be derived from methionine by a triple transmethylation process (2). Cysteine appears to be an immediate precursor of the sulfur atom of the thiolimidazole rin...
متن کاملBiosynthesis of Ergothioneine and Hercynine by Mycobacteria.
Genghof, Dorothy S. (Yeshiva University, New York, N.Y.), and Olga Van Damme. Biosynthesis of ergothioneine and hercynine by mycobacteria. J. Bacteriol. 87:852-862. 1964.-Ergothioneine and hercynine were found to be synthesized by a wide variety of mycobacteria grown in chemically defined media free from these compounds. The cultures examined included 53 recently isolated and laboratory strains...
متن کاملBiosynthesis of ergothioneine from endogenous hercynine in Mycobacterium smegmatis.
Ergothioneine was synthesized and accumulated in growing cultures of Mycobacterium smegmatis when the medium was adequately supplied with sulfur. In a low sulfur medium, the accumulation was sharply limited although growth of the organism was apparently normal. Synthesis of hercynine, the precursor of ergothioneine, was unaffected by low sulfur levels and was markedly increased by addition of l...
متن کاملThe biosynthesis of ergothioneine.
The recent finding that ergothioneine is synthesized by many common fungi (1) has led us to investigate the pathway of biosynthesis. In view of the relatively high concentrations of the substance found in Neurospuru crussa, this organism was selected for study. The results provide strong evidence to show that ergothioneine (I) is derived from hi&dine, that cysteine provides the sulfhydryl, grou...
متن کاملIdentification of the Main Intermediate Precursor of l-Ergothioneine Biosynthesis in Human Biological Specimens.
A capillary electrophoresis coupled to tandem mass spectrometry (CE-MS/MS) has been used to make a qualitative determination of hercynine-the main precursor of l-ergothioneine biosynthesis-in some key human biological specimens, such as urine, whole blood, plasma, and saliva. From semiquantitative analysis results, the highest concentrations of hercynine were detected in saliva and whole blood,...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1962
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)83750-x